Human ACE2

The Human ACE2/TMPRSS2 Stable Cell Line (CSC-RO066) from Creative Biogene represents a significant advancement in the study of viral interactions, specifically in the context of SARS-CoV-2 infection. This engineered cell line co-expresses human Angiotensin I Converting Enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) in HEK293T cells, making it a pivotal tool for understanding how SARS-CoV-2 enters host cells. Key Features and Applications1. Mechanistic StudiesThis cell line facilitates detailed investigations into the mechanics of viral entry. By examining the cleavage of the SARS-CoV-2 spike protein by TMPRSS2, researchers can uncover the coordinated steps that the virus employs to gain entry into human cells. Understanding these interactions is crucial for identifying potential therapeutic targets. 2. Drug DiscoveryThe versatility of the Human ACE2/TMPRSS2 Stable Cell Line makes it an excellent platform for high-throughput screening of antiviral compounds. Researchers can efficiently identify molecules that inhibit the interaction between the virus and its receptors, paving the way for novel antiviral strategies. 3. Vaccine DevelopmentThis cell line is invaluable in vaccine research, offering a model to evaluate the effectiveness of vaccines. By assessing how well candidate vaccines can prevent viral entry and stimulate immune responses, developers can optimize vaccine formulations for better protection against COVID-19. 4. Quality Control and StandardsThe cell line is rigorously tested, ensuring that it is free from contaminants such as bacteria, yeast, and mycoplasma. It is maintained under stringent growth conditions, supporting reliable and consistent experimental outcomes across various applications.